Communications at national and international scientific meetings

  1. NRF2 deficiency in mice replicates transcriptomic alterations found in brain of elderly and Alzheimer’s disease patients and aggravates APP and TAU pathology. Antonio Cuadrado, EMBO (European Molecular Biology Organization), 16-23.07.2017, Sankt Petersburg, Rusia.
  2. NRF2 modulates neuroinflammation in Alzheimer’s disease, Antonio Cuadrado. A 47-a Conferinţă Anuală de Imunologie cu participare internaţională, 4-6.10.2017, Bucuresti, Romania.
  3. The NRF2-Neuroinflammation Network in Alzheimer’s Disease. Antonio Cuadrado. Conferinta Anuala a INCD „Victor Babes” si al 10-lea Simpozion de Patologie, 23-25.11.2017, Bucuresti, Romania
  4. The transcription factor NRF2: a new brain protective strategy in Alzheimer’s disease. Antonio Cuadrado. Seminar organizat de Basque Center for Neurosciences, 25.05.2018, Achucarro Mintegiak, Bilbao, Spania.
  5. The role of Nrf2 in neurodegenerative diseases. Antonio Cuadrado, Ana I. Rojo. Workshop – Transcription factor NRF2: New opportunities for pharmaceutical innovations in chronic diseases, 11-13.04.2018, Madrid, Spania.
  6. Neuroprotective effects of NRF2 in neurodegeneration. Antonio Cuadrado. International course “Mitochondria and ROS signalling”, 12-14.06.2018, University of Eastern Finland, Kuopio, Finland.
  7. Inflammation, oxidative stress and Alzheimer: a preliminary gene expression study. Dobre Maria, Milanesi Elena, Manda Gina, Cuadrado Antonio. Aging 2018 – Bordeaux Neurocampus Conferences, 26-28.09.2018, Bordeaux, Franta.
  8. Potential role of NRF2 in Alzheimer’s disease as a crucial modulator of the innate immune suppression. Rojo Ana, Milanesi Elena, Pajares Marta, Mihai Simona, Surcel Mihaela, Lopez-Colazzo Eduardo, Varel A, Manda Gina, Cuadrado Antonio. Aging 2018 – Bordeaux Neurocampus Conferences, 26-28.09.2018, Bordeaux, Franta.
  9. Molecular profiles in Alzheimer disease – The REDBRAIN project after two year. Antonio Cuadrado, Elena Milanesi, Michel Edwar Mickael, Bogdan Ovidiu Popescu, Gabriel Prada, Ovidiu Bajenaru, Catalina Tudose, Luiza Spiru, Gina Manda. Sesiunea Stiintifica Anuala a INCD „Victor Babes” si al 11-lea Simpozion National de Patologie, 22-24.11.2018, Bucuresti, Romania.
  10. 8 Arm Radial Maze test for assessement of memory performance in Nrf2-/- mice. Grigoras Stefania, Tiron Radu Ioan, Stefan Andreea Elena, Neagoe Ionela Victoria, Enciu Ana-Maria. Sesiunea Stiintifica Anuala a INCD „Victor Babes” si al 11-lea Simpozion National de Patologie, 22-24.11.2018, Bucuresti, Romania.
  11. Age-related gene expression changes: oxidative stress, inflammation, environment and cognition. Elena Milanesi, Maria Dobre, Ionela Victoria Neagoe, Mihaela Surcel, Gheorghita Isvoranu, Bogdan Ovidiu Popescu, Antonio Cuadrado. Sesiunea Stiintifica Anuala a INCD „Victor Babes” si al 11-lea Simpozion National de Patologie, 22-24.11.2018, Bucuresti, Romania.
  12. La enfermedad de Alzheimer: de la neurodegeracion a la neuroproteccion. Antonio Cuadrado. Seminariile „Progrese in Biomedicina”, 1.02.2019, Facultatea de Medicina, Ciudad Real, Spania.
  13. Transcription factor NRF2 modulates chaperone mediated autophagy. Seminar – Instituto de Investigación Sanitaria “La Paz” (IdiPAZ), 29.04.2019, Madrid, Spain.
  14. New advances in the search for beta-TrCP or KEAP1 Protein-Protein Interaction (PPI) inhibitors. Seminar – Department of Pharmacology, Medical College, Autonomous University of Madrid, 15.05.2019, Madrid Spania.
  15. Oxidative stress and inflammation gene expression changes in cognitive impairment. Elena Milanesi, Maria Dobre, Bogdan Ovidiu Popescu, Gabriel Prada, Ovidiu Bajenaru, Catalina Tudose, Luiza Spiru, Gina Manda, Antonio Cuadrado. The 44th FEBS Congress, 6-11.07.2019, Krakow, Polonia.
  16. Targeting NRF2 for brain protection and monitoring biomarker in Alzheimer’s disease. Antonio Cuadrado, Elena Milanesi, Maria Dobre,  Marta Pajares, Bogdan O. Popescu, Ana I. Rojo, Gerard Piñol, Gina Manda. The Environmental Response V /17th JBS Biofrontier Symposium, 12-14.09.2019, Sendai, Japonia.
  17. Inflamación y estrés oxidativo en enfermedades neurodegenerativas. Antonio Cuadrado. INN0 UAM_Neuro, 24.10.2019, Madrid Spania.
  18. Cognitive evaluation method in NRF2-KO mice using the eight-arm radial maze. Catalina Anca Cucoș, Ana-Maria Enciu, Laurențiu Anghelache. Sesiunea Anuala a INCD „Victor Babes” si al 12-lea Simposion National de Patologie, 21-23.11.2019, București, Romania. 
  19. Transcriptional signatures of NRF2 and NFkB as blood biomarkers in dementia. A Cuadrado, E. Milanes, M. Dobre, G. Piñol, G. Manda. XL Congreso del Grupo Español de Neurotransmisión y Neuroprotección (GENN), 18-21.12.2019, Segovia, Spania.
  20. Targeting oxidative and inflammatory stress for brain protection and biomarker monitoring in Alzheimer’s disease, Antonio Cuadrado, CIBERNED Meeting, 20.10.2020, Madrid, Spania.
  21. Blood transcript signatures in mild dementia: a targeted transcriptomics study, Antonio Cuadrado, Elena Milanesi, Maria Dobre, Anca Cucos, Gerard Piñol-Ripoll, Gabriela Niculescu, Gina Manda. Annual Scientific Meeting & 13th National Pathology Symposiun, 5-7.11.2020, INCD “Victor Babes” (https://www.ivb.ro/v3/project/symposium/)

 

Project Promotion

 

  1. Alzheimer’s disease from the redox signaling perspective – the REDBRAIN project, Gina Manda, Ana-Maria Enciu, Antonio Cuadrado A. A 46-a Conferinţă Anuală de Imunologie cu participare internaţională, 5-7.10.2016, Bucuresti, Romania. Publicat in volumul de rezumate al conferintei C7, pg 27.
  2. Alzheimer’s disease from a redox perspective: The REDBRAIN project Antonio Cuadrado. Bench to Bed Research on the Transcription Factor NRF2, 19.10.2016, Medical College of the Autonomous University of Madrid (La Pagoda), Madrid Spania.
  3. The REDBRAIN project, Antonio Cuadrado. New concepts and views in redox biology and oxidative stress research – achievements of COST Action BM1203 (EU-ROS)”, organizată în perioada 7-10 noiembrie 2016, în Eilat, Israel.

Publications

  1. Pietro Ghezzi, Luciano Floridi, Diana Boraschi, Antonio Cuadrado, Gina Manda, Snezana Levic, Fulvio D’Acquisto, Alice Hamilton, Toby J Athersuch, Liza Selley. Oxidative stress and inflammation induced by environmental and psychological stressors: a biomarker perspective. Antioxidants and Redox Signaling, May 2017, 28(9):852-872. doi: 10.1089/ars.2017.7147. Factor de impact 6.73. https://www.liebertpub.com/doi/abs/10.1089/ars.2017.7147?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=ars
  2. Ana I Rojo, Marta Pajares, Patricia Rada, Angel Nuñez, Alejo J. Nevado-Holgado, Richard Killik, Fred Van Leuven, Elena Ribe, Simon Lovestone, Masayuki Yamamoto and Antonio Cuadrado. NRF2 deficiency replicates transcriptomic changes in Alzheimer’s patients and worsens APP and TAU pathology. Redox Biology, October 2017, 13:444-451. doi: 10.1016/j.redox.2017.07.006. Factor de impact 6.76. http://www.sciencedirect.com/science/article/pii/S2213231717303993
  3. Cuadrado A, Manda G, Hassan A et al. Transcription factor NRF2 as a therapeutic target for degenerative diseases: a systems medicine approach, Pharmacol Rev, 2018 Apr, 70(2):348-383. doi: 10.1124/pr.117.014753. Factor de impact 18.886 http://pharmrev.aspetjournals.org/content/pharmrev/70/2/348.full.pdf
  4. Adva Hadar, Elena Milanesi, Marta Walczak, M Puzianowska-Kuznicka, Jacek Kuźnicki, Alessio Squassina, Paola Niola, Caterina Chillotti, Johannes Attems, Illana Gozes, David Gurwitz. SIRT1, miR-132 and miR-212 link human longevity to Alzheimer’s Disease. Scientific Reports 2018, May, doi: 8(1):8465, doi:1038/s41598-018-26547-6. Factor de impact 4.12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981646/pdf/41598_2018_Article_26547.pdf
  5. Natalia Robledinos-Antón, Raquel Fernández-Ginés, Gina Manda and Antonio Cuadrado. Activators and inhibitors of NRF2: a review of its clinical development, Oxidative Medicine and Cellular Longevity, 2019 July, 2019:9372182. doi: 10.1155/2019/9372182. Factor de impact 4.580
  6. Ansari A, Maffioletti E, Milanesi E, Marizzoni M, Frisoni GB, Blin O, Richardson JC, Bordet R, Forloni G, Gennarelli M, Bocchio-Chiavetto L; PharmaCog Consortium. miR-146a and miR-181a are involved in the progression of mild cognitive impairment to Alzheimer’s disease. Neurobiol Aging, 2019 Oct, 82:102-109. doi: 10.1016/j.neurobiolaging.2019.06.005. Factor de impact 347.
  7. Gina Manda, Ana I. Rojo, Elena Martínez-Klimova, José Pedraza-Chaverri and Antonio Cuadrado. Nordihydroguaiaretic acid: from herbal medicine to clinical development for cancer and chronic diseases. Frontiers in Pharmacology, sectiunea Experimental Pharmacology and Drug Discovery, Front Pharmacol. 2020 Feb 28;11:151. doi: 10.3389/fphar.2020.00151. PMID: 32184727. Factor de impact 4.225.
  8. Mickael ME, Pajares M, Enache I, Manda G, Cuadrado A. NRF2 drug repurposing using a question-answer artificial intelligence system. 2019 Jan, doi: https://doi.org/10.1101/594622, https://www.biorxiv.org/content/10.1101/594622v1.full.pdf
  9. Maffioletti E, Milanesi E, Ansari A, Zanetti O, Galluzzi S, Geroldi C, Gennarelli M, Bocchio-Chiavetto L. miR-146a Plasma Levels Are Not Altered in Alzheimer’s Disease but Correlate With Age and Illness Severity Front Aging Neurosci, 2020 Jan, 17;11:366. doi: 10.3389/fnagi.2019.00366. eCollection 2019. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978630/. Impact factor 4.364
  10. Norwin Kubick, Marta Pajares, Ioana Enache, Gina Manda, Michel-Edwar Mickael. Repurposing Zileuton as a Depression Drug Using an AI and In Vitro Approach. Molecules 2020, 25(9), 2155; https://doi.org/10.3390/molecules25092155 Factor de impact 3.267
  11. Antonio Cuadrado, Cristina Benito, José Jiménez-Villegas, Maribel Escoll, Raquel Fernández-Ginés, Angel J. Garcia Yagüe, Diego Lastra, Gina Manda, Marta Pajares1, Ana I. Rojo and Albena T. Dinkova-Kostova. Can Activation of NRF2 Be a Strategy against COVID-19?, Trends in Pharmacological Sciences, 2020 Sep; 41(9): 598–610. Factor de impact: 11.523
  12. Marta Pajares, Ana I. Rojo, Gina Manda, Lisardo Boscá, Antonio Cuadrado. Neuroinflammation in Parkinson’s disease: mechanisms and therapeutic implications, Cells 2020, 9(7), 1687; https://doi.org/10.3390/cells9071687, factor de impact 366
  13. Capitol de carte cu titlul “Perspectives on the Clinical Development of NRF2-Targeting Drugs”, autori: Lastra Diego, Raquel Fernandez-Gines, Gina Manda, Antonio Cuadrado, din cadrul cartii cu titlul “Reactive Oxygen Species: Sources, Targets and Therapeutic Implications”, Handbook of Experimental Pharmacology, editura Springer Nature, editori: Schmidt, Harald H.H.W.; Ghezzi, Pietro; Cuadrado, Antonio. DOI: 10.1007/164_2020_381)
  14. Gina Manda, Antonio Cuadrado. The transcription factor NRF2 shapes the identity of radio-resistant tumor cells. Journal of Cell Identity, October 20, 2020, vol. 1, p. 0049-0081. DOI 10:47570/joci.2020.004.
  15. Norwin Kubick, Patrick C. Henckell Flournoy, Pavel Klimovich, Gina Manda, Michel‐Edwar Mickael. What has single‐cell RNA sequencing revealed about microglial neuroimmunology? Immunology, Inflammation and Disease 2020, https://doi.org/10.1002/iid3.362. Factor de impact 2.5.
  16. Norwin Kubick, Patrick C Henckell Flournoy, Ana-Maria Enciu, Gina Manda, Michel-Edwar Mickael. Drugs Modulating CD4+ T Cells Blood–Brain Barrier Interaction in Alzheimer’s Disease. Pharmaceutics, 12(9), 880, 2020. Factor de impact 4.421.
  17. Elena Milanesi, Gina Manda, Maria Dobre, Elena Codrici, Ionela V. Neagoe, Bogdan O. Popescu, Alexandru O. Bajenaru, Luiza Spiru*, Catalina Tudose, Gabriel I. Prada, Eugenia I.V. Davidescu, Gerard Piñol-Ripoll, Antonio Cuadrado. Distinctive under-expression profile of inflammatory and redox genes in the blood of elderly patients with cardiovascular disease, Journal of Inflammation Research, 18 Feb 2021, 14:429-442, DOI: 10.2147/jir.s280328, PMID: 33658823, PMCID: PMC7917358, https://europepmc.org/article/PMC/PMC7917358. Factor de impact 4.953.