General objective

To develop and strengthen R&D and innovative competitiveness of “Victor Babes” National Institute of Pathology (IVB) by building new skills and transferring knowledge in order to create a highly competitive scientific team, able to conduct cutting edge research in neurosciences addressing neurodegenerative and neuroinflammatory diseases with a main focus in Alzheimer’s disease.


Specific objectives

  1. to implement at IVB new directions of applied research with high potential of innovation in therapeutics of neurodegenerative diseases: a)  to apply redox biology concepts and tools to investigated molecular mechanisms and biomarkers in blood, related to the fingerprint of the transcription factor Nrf2, that underly pathophysiological processes in Alzheimer’s diseases, and provide a tool for monitoring disease or therapy; b)  to use state-of-the-art “multiplex” approaches (genomic and proteomic) for elucidating molecular networks related to oxidative stress and inflammation in the progression of this chronic disease;

  2. to increase international visibility of IVB by publications in highly-ranked journals, hence reinforcing its capability to participate in large scale projects in the frame of Horizon 2020 and other EU or non-EU programmes;

  3. to better connect the fundamental and applied research developed at IVB to international research priorities in neurodegenerative and neuroinflammatory diseases by joining dedicated EU networks;

  4. to increase collaboration with biotechnology / pharmaceutical industry by offering advanced research services for the screening and preclinical investigation of next-generation small molecule drugs;

  5. to valorize through competitive research the state-of-the-art research infrastructure has been recently built at IVB with support from the Sectoral Operational Programme “Increase of Economic Competitiveness” 2007-2013;

  6. to attract brilliant scholars and young scientists and to train them in a highly competitive scientific environment at IVB.