Activity Sub-activity Type of Activity Duration Quantified Results
Eligible Non-eligible Full Duration

(no. of months)

Starting Date

(month)

End Date

(month)

(1) (2) (3) (4) (5) (6) (7) (8)
Activities of fundamental research – NOT THE CASE
Activities of industrial research
Activity 1

Industrial research

Case-control study on Nrf2 signature in Alzheimer’s disease (AD) and mild cognitive impairment (MCI)

1.1     Sub-activity 1.1.

Design of the case-control study

X   6 1 6 1 case-control study design

7 preliminary Standard Operating Procedures

1.2    Sub-activity 1.2.

Case-control study on Nrf2 signature in AD and MCI

X   34 7 40 Biological samples

1 database with demografic, clinical and biological data of AD patients, MCI patients and controls

1 study report

1.3    Sub-activity 1.3.

Set-up of the study-specific biobank

X   37 5 41 1 case-control study-specific biobank

1 biological samples registry

1.4    Sub-activity 1.4.

Set-up of patients data repository

X   37 5 41 1 data repository of the cross-sectional study
1.5    Sub-activity 1.5.

Statistical processing of data and connection of data in redox networks

X   10 37 46 1 case-control study report

1 redox network in AD and MCI as compared to controls

Activity 2

Industrial research

Proof-of-principle study on pharmacological modulation of Nrf2 signature in  preclinical models of Alzheimer’s disease

2.1 Sub-activity 2.1.

Design of thepreclinical proof-of-principle study

X   5 13 17 1 report on the preclinical study design

6 preliminary Standard Operating Procedures

2.2 Sub-activity 2.2.

Selection of preclinical models relevant for Nrf2 signature in Alzheimer’s disease

X   12 18 29 1 selected animal model of disease relevant for Nrf2 signature in AD
2.3 Sub-activity 2.3.

Preclinical proof-of-principle study based on pharmacological activation of Nrf2 in Alzheimer’s disease

X   13 30 42 1 study report on the clinical status and behaviour of animals during experiments

1 study report on the dynamics of hematological and biochemical parameters of experimental animals

2.4 Sub-activity 2.4.

Set-up of the preclinical study biobank

    28 16 43 1 precinical study- dedicated biobank

1 biological samples registry

2.5 Sub-activity 2.5.

Set-up of the preclinical study database

    28 16 43 1 preclinical study database
2.6 Sub-activity 2.6.

Statistical processing of data and interpretation of results

    10 37 46 1 network of altered redox and inflammation processes in experimental AD models

1 report on the impact of Nrf2 activators on AD onset and  progression in experimental models of disease, in connection with changes elicited by the treatment at the level of Nrf2 signature

Activity 3

Industrial research

Elaboration of  final study-specific Standard Operating Procedures

3.1 Sub-activity 3.1.

Elaboration of final study-specific Standard Operating Procedures

X   3 45 47 13 Standard Operating Procedures
Activity 4

Industrial research

Implementation of redox biology tools at IVB

4.1. Sub-activity 4.1.

Elaboration of training materials

X   4 5 8 5 powerpoint presentations on redox biology experimental tools

4 Standard Operating Procedures for particular redox biology experimental tools

4.2. Sub-activity 4.2.

On-line training

X   4 9, 21,

33, 44

9, 21,

33, 44

4 sessions of on-line training on redox biology concepts and investigational tools
4.3. Sub-activity 4.3.

On-site training

X   4 11, 23,

35, 47

11, 23,

35, 47

4 hands-on training sessions on experimental methods for investigating the redox status and the antioxidant resonse
4.4 Sub-activity 4.4.

Show-and-tell workshop

X   1 47 47 1 show-and-tell workshop

3 PowerPoint presentations

Promotion materials:10 posters, 50 bags with brochure, USB, pens

15 feedback questionnaires

Activity 5

Industrial research

Dissemination of results

5.1 Sub-activity 5.1. Dissemination of scientific results generated in the project
Publication of results X   36 13 48 At least 8 articles with original results out of which 3 articles will be published in collaboration with private companies

1 review article

Communication of results X   40 9 48 At least 12 communications at national and international meetings out of which 4 will be published in collaboration with private companies
Elaboration and submission of the documentation for patenting original results obtained in the project X   12 37 48 Documentation for 1 patent/1 panel of biomarkers submitted to the Romanian Office for Inventions and Trademarks and/or similar EU patent offices
Joining of new European scientific networks/platforms  in the field of the project X   24 25 48 Membership to at least 1 European network in the field of the project
Industry showcase X   2 34 35 1 industry show case

50 invitations,3 PowerPoint presentations

Promotion materials:10 posters, 1 banner, 50 bags with brochure, USB, pens

Specific agreements between relevant biopharmaceutical companies and IVB for collaborative RDI work

Knowhow and technology transfer to private companies X   12 37 48 1 documentation for knowhow and technology transfer
Activities of experimental development – NOT THE CASE
Activity of preparing the feasibility study for experimental development – NOT THE CASE
Activities for obtaining, validating and protecting the industrial property rights – NOT THE CASE
Information and publicity
Activity 6

Information and publicity

6.1 Sub-activity 6.1. Information and publicity for the project            
Set-up of the project-dedicated web page X   48 1 48 1 project-dedicated web page
Project’s opening and closing conferences X   1 4, 47 4, 47 2 conference programs; 100 invitations

10 posters, 2 banner1 and 1 roll-up for publicity; 80 bags containing a brochure, USB and pen, along with project promotion documents; 6 PowerPoint presentations;

50 feed-back questionnaires from participants

Publication of project promotion articles X   48 1 48 3 project promotion articles
Activity 7

Project management

7.1 Sub-activity 7.1.

General coordination and monitoring of the project

X   48 1 48 4 internal progress reports
7.2 Sub-activity 7.2.

Detailed planning of work and responsibilities assignment

X   48 1 48 16 work plans
7.3 Sub-activity 7.3.

Alocation and management of resources

X   48 1 48 4 detailed plans correlating activities with financial, human and material resources
7.4 Sub-activity 7.4.

Procurement of material resources

X   48 1 48 8 procedures of aquisition and corresponding documentation (2 sessions per year estimated)
7.5 Sub-activity 7.5.

Management meetings

X   48 1 48 8 management meetings (2 per year)

8 management meetings reports

7.6 Sub-activity 7.6.

Scientific meetings of the team

X   48 1 48 8 scientific meatings (2 per year)

8 scientific meeting reports

7.7 Sub-activity7.7.

Work group meetings

X   48 1 48 48 meetings of the implementation team ( monthly meetings)

Meeting reports

7.8 Sub-activity 7.8.

Reporting

X   46 3 48 12 intermediary reports (at three months)

1 final report

Final report
Activity 8

Intermediary and final audits for the project

8.1 Sub-activity 8.1.

Preparation of the audit documentation

X   4 1 48 4 audit documentations
8.2 Sub-activity 8.2.

Audits

  X 8 11-12, 23-24, 35-36, 47-48 11-12, 23-24, 35-36, 47-48 4 audit certificates and reports

 

Gantt Diagram